Deficiency of PRKD2 triggers hyperinsulinemia and metabolic disorders
نویسندگان
چکیده
منابع مشابه
Immunoproteasome subunit LMP7 Deficiency Improves Obesity and Metabolic Disorders
Inflammation plays an important role in the development of obesity and metabolic disorders; however, it has not been fully understood how inflammation occurs and is regulated in their pathogenesis. Low-molecular mass protein-7 (LMP7) is a proteolytic subunit of the immunoproteasome that shapes the repertoire of antigenic peptides on major histocompatibility complex class I molecule. In this stu...
متن کاملIODINE DEFICIENCY DISORDERS IN NEISHABOUR
Iodine deficiency has been considered in Iran since 20 years ago and has been acknowledged recently. We studied iodine deficiency disorders in 1618 Neishabourian students. 60% of children had palpable and 2.5% had visible goiters. Height and weight of these children were lower than International and Tehranian children but higher than Isfahanian children. Hormone studies showed increased T4...
متن کاملCockayne syndrome: a case with hyperinsulinemia and growth hormone deficiency.
Cockayne syndrome is a rare autosomal recessive disorder of childhood characterized by cachectic dwarfism with senile-like appearance, mental retardation, photosensitive dermatitis, loss of adipose tissue, pigmentary degeneration of retina, microcephaly, deafness, skeletal and neurologic abnormalities. We describe here an 18 year old boy with Cockayne syndrome who had, in addition to the typica...
متن کاملFood triggers and inherited metabolic disorders: a challenge to the pediatrician
Several disorders should be considered in the case of newborns and infants experiencing acute or recurrent symptoms after food ingestion. Immune-mediated adverse food reactions are the most frequent and always to be considered. Nevertheless, in the extensive differential diagnosis, clinicians should also include inherited metabolic disorders (IMDs).This review reports clinical features and diag...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Communications
سال: 2018
ISSN: 2041-1723
DOI: 10.1038/s41467-018-04352-z